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Guanosine 5′-O-(2-Thiodiphosphate), Trilithium Salt

Non-hydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs. Stimulates adenylate cyclase activity in sarcolemmal membranes by inactivating Gi proteins.

Synonym(s):

Guanosine 5′-O-(2-Thiodiphosphate), Trilithium Salt, GDP-β-S, 3Li

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About This Item

Empirical Formula (Hill Notation):
C10H12N5O10P2S · 3Li
CAS Number:
97952-36-8
Molecular Weight:
477.07
MDL number:
MFCD00057735
UNSPSC Code:
12352208

Quality Level

100

Assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

LMCWQGPJYZRMKU-CYCLDIHTSA-K

General description

A nonhydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs.
Non-hydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs. Stimulates adenylate cyclase activity in sarcolemmal membranes by inactivating Gi proteins.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose 5% of their activity after 6 months at -20°C.

Other Notes

Piacentini, L., et al. 1996. Biochim. Biophys. Acta1282, 11.
Eberhard, D.A. and Holz, R.W., et al. 1991. Biochem J.279, 447.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Burch, R.M., et al. 1987. Proc. Natl. Acad. Sci. USA84, 6374.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Eckstein, F., et al. 1979. J. Biol. Chem.254, 9829.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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