368059-M
Granzyme B Substrate II, Fluorogenic
A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.
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Synonym(s):
Granzyme B Substrate II, Fluorogenic, Z-IETD-AFC, Caspase-8 Substrate II
Empirical Formula (Hill Notation):
C37H42F3N5O13
Molecular Weight:
821.75
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 1 mg/mL
fluorescence
λex ~400 nm
λem ~505 nm
storage temp.
−20°C
General description
A fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
A fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
Biochem/physiol Actions
Primary Target
Fluorogenic substrate for the detection of granzyme B and caspase-8 activity
Fluorogenic substrate for the detection of granzyme B and caspase-8 activity
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Ile-Glu-Thr-Asp-AFC
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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