365252
Gö 7874, Hydrochloride
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC).
Synonym(s):
Gö 7874, Hydrochloride, MLCK Inhibitor III
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About This Item
Empirical Formula (Hill Notation):
C27H26N4O4 · xHCl
CAS Number:
Molecular Weight:
470.52 (free base basis)
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
amber
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC). Inhibits protein kinase A (IC50 = 510 nM), protein kinase G (IC50 = 4.8 µM), and myosin light chain kinase (IC50 = 120 nM) at much higher concentrations.
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of rat brain protein kinase C (IC50 = 4 nM) versus myosin light chain kinase (IC50 = 0.12 µM), protein kinase A (IC50 = 510 nM), and protein kinase G (IC50 = 4.8 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
PKC
Product competes with ATP.
Reversible: yes
Target IC50: 4 nM against rat brain PKC
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett.5, 55.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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