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361568

Sigma-Aldrich

GSK-3β Inhibitor XXV

The GSK-3β Inhibitor XXV controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

GSK-3β Inhibitor XXV, 5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC

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About This Item

Empirical Formula (Hill Notation):
C15H11ClN4O3
CAS Number:
1257256-44-2
Molecular Weight:
330.73
MDL number:
MFCD22683811
UNSPSC Code:
12352200

Quality Level

100

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

CC(C=C1)=C(Cl)C=C1NC2=NN=C(C3=CC=C(C=C3)[N+]([O-])=O)O2

General description

A blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Khanfar, M.A., et al. 2010. J. Med. Chem.53, 8534.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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