All Photos(1)
Synonym(s):
InSolution GSK-3 Inhibitor IX
Empirical Formula (Hill Notation):
C16H10BrN3O2
CAS Number:
Molecular Weight:
356.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
2-8°C
General description
A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk′s (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: no
Target IC50: 5 nM against GSK-3α/β
Packaging
Packaged under inert gas
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Physical form
A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Other Notes
Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
188.6 °F
Flash Point(C)
87 °C
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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