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361515

Sigma-Aldrich

Glycogen Phosphorylase Inhibitor

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

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Synonym(s):
Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
Empirical Formula (Hill Notation):
C17H15ClF2N4O4
CAS Number:
648926-15-2
Molecular Weight:
412.78
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)

InChI key

ROJNYKZWTOHRNU-UHFFFAOYSA-N

General description

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Glycogen phosphorylase
Product does not compete with ATP.
Reversible: no
Target IC50: 53 nM against glycogen phosphorylase

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Qian Zheng et al.
Theranostics, 11(18), 8674-8691 (2021-09-16)
Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden, unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) gene and histone modifier genes. Besides, poor survival rates of ccRCC patients seem to be associated with up-regulation
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
Kasandra S Hunter et al.
Frontiers in microbiology, 12, 726465-726465 (2021-09-21)
On entering the mammalian host, schistosomes transition from a freshwater environment where resources are scarce, to an environment where there is an unlimited supply of glucose, their preferred energy substrate. Adult schistosome glycolytic activity consumes almost five times the parasite's
Nont Kosaisawe et al.
Cell metabolism, 33(3), 649-665 (2021-02-10)
Cell-to-cell heterogeneity in metabolism plays an unknown role in physiology and pharmacology. To functionally characterize cellular variability in metabolism, we treated cells with inhibitors of oxidative phosphorylation (OXPHOS) and monitored their responses with live-cell reporters for ATP, ADP/ATP, or activity

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