345752
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.
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Synonym(s):
Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk, Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
Empirical Formula (Hill Notation):
C70H123N3O30 · 2NH4
Molecular Weight:
1522.80
UNSPSC Code:
12352211
NACRES:
NA.77
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Quality Level
Assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
chloroform/methanol (2:1): soluble
shipped in
ambient
storage temp.
−20°C
General description
Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
Warning
Toxicity: Irritant (B)
Other Notes
DeMaria, R., et al. 1997. Science 277, 1652.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Sumeyye Cavdarli et al.
Cells, 10(6) (2021-07-03)
The O-acetylated form of GD2, almost exclusively expressed in cancerous tissues, is considered to be a promising therapeutic target for neuroectoderm-derived tumors, especially for breast cancer. Our recent data have shown that 9-O-acetylated GD2 (9-OAcGD2) is the major O-acetylated ganglioside
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