344935
Furin Substrate, Fluorogenic
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).
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Synonym(s):
Furin Substrate, Fluorogenic
Empirical Formula (Hill Notation):
C37H57N13O9
Molecular Weight:
827.93
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 10 mg/mL
DMSO: soluble
fluorescence
λex 360 - 380 nm
λem 430-460 nm
shipped in
ambient
storage temp.
−20°C
General description
A fluorogenic substrate for furin (kcat/Km ~2 X 104 M-1 s-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (kcat/Km ~6 X 103 M-1 s-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 104 s-1M-1).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Fluorogenic substrate for furin
Fluorogenic substrate for furin
Product does not compete with ATP.
Reversible: no
kcat/Km ~ 2 x 104 s-1M-1 for furin
Warning
Toxicity: Standard Handling (A)
Sequence
Pyr-Arg-Thr-Lys-Arg-AMC
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lamango, N.S., et al. 1996. Arch. Biochem. Biophys.330, 238.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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