344931-M
Furin Inhibitor II
The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Synonym(s):
Furin Inhibitor II, Hexa-D-arginine, H-(D)RRRRRR-NH₂
Empirical Formula (Hill Notation):
C36H75N25O6
Molecular Weight:
954.14
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
DMSO: soluble
storage temp.
−20°C
General description
A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.
A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.
Biochem/physiol Actions
Primary Target
furin
furin
Target Ki: 106 nM against Furin
Warning
Toxicity: Standard Handling (A)
Sequence
H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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