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344911

Sigma-Aldrich

Fura-2 LR/AM

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound.

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Synonym(s):
Fura-2 LR/AM, Fura-2 Leakage Resistant (AM)
Empirical Formula (Hill Notation):
C55H63N5O29
CAS Number:
172890-84-5
Molecular Weight:
1258.10
MDL number:
MFCD00285848
UNSPSC Code:
12171500
NACRES:
NA.25

Quality Level

100

Assay

≥95% (HPLC)

form

gum

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

fluorescence

λex 368 nm (low)
λex 374 nm (high)
λem 518 nm (low)
λem 524 nm (high)

shipped in

ambient

storage temp.

−20°C

InChI

1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3

InChI key

CGAZNAYDEAJZHQ-UHFFFAOYSA-N

General description

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM. Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2, it is retained longer in the cell. Note: 1 set = 10 x 50 µg.
An acetoxymethyl (AM) derivative of FURA-PE3. with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM (Cat. No. 344905). Hydrolysis by non-specific esterases traps the indicator in the cytosol. Spectral properties in the presence of low calcium concentrations (ex. 364 nm, em. 508 nm) differ from those during high calcium conditions (ex. 335 nm, em. 495 nm). Note: 1 set = 10 x 50 µg.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Calcium Probes
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Abe, F., et al. 1995. Br. J. Pharmacol.116, 3000.
Vorndran, C., et al. 1995. Biophys. J.69, 2114.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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