344215
Formononetin
A phytoestrogenic isoflavone found in soy-based foods.
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Synonym(s):
Formononetin, 7-Hydroxy-3-(4ʹ-methoxyphenyl)-4H-benzopyran-4-one
Empirical Formula (Hill Notation):
C16H12O4
Recommended Products
Quality Level
Assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
methanol: 2 mg/mL
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
InChI key
HKQYGTCOTHHOMP-UHFFFAOYSA-N
General description
A non-steroidal phytoestrogenic isoflavone found in soy-based food products. Has been shown to interact with human estrogen receptor with relatively low potency. Induces mammary gland proliferation in mice. Inhibits lecithin peroxidation induced by hydroxyl radicals. Also acts as a selective inhibitor of γ-isoform of alcohol dehydrogenase.
A phytoestrogenic isoflavone found in soy-based foods. Displays potent antioxidant properties and acts as a selective inhibitor of the γ-isoform of alcohol dehydrogenase. Shown to interact with human estrogen receptors with low potency. Induces mammary gland proliferation in mice.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Selective inhibitor of the γ-isoform of alcohol dehydrogenase
Selective inhibitor of the γ-isoform of alcohol dehydrogenase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not re-freeze any thawed aliquots.
Other Notes
Pool-Zobel, B.L., et al. 2000. Carcinogenesis 21, 1247.
Toda, S., and Shirataki, Y. 1999. Phytother. Res.13, 163.
Ruiz-Larrea, M.B., et al. 1997. Free Radic. Res.26, 63.
Keung, W.M. 1995. Biochem. Biophys. Res. Commun.215, 1137.
Wang, W., et al. 1995. Nutr. Cancer23, 131.
Miksicek, R.J. 1994. J. Steroid Biochem. Mol. Biol.49, 153.
Toda, S., and Shirataki, Y. 1999. Phytother. Res.13, 163.
Ruiz-Larrea, M.B., et al. 1997. Free Radic. Res.26, 63.
Keung, W.M. 1995. Biochem. Biophys. Res. Commun.215, 1137.
Wang, W., et al. 1995. Nutr. Cancer23, 131.
Miksicek, R.J. 1994. J. Steroid Biochem. Mol. Biol.49, 153.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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