341482
Ferritin, Human Liver
Ferritin, Human Liver, CAS 9007-73-2, is a native, sterile-filtered ferritin that is suitable for use in immunoassays, as an immunogen, and in enzyme/radiolabeling.
Synonym(s):
Ferritin, Human Liver
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About This Item
biological source
human
Quality Level
Assay
≥95% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
technique(s)
enzyme immunoassay: suitable
impurities
Antibodies to HIV1, HIV2, Hepatitis B, Hepatitis C, tested negative (by certified tests)
solubility
water: soluble
suitability
suitable for immunoassay
Protein ID accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... FTH1(2495) , FTL(2512)
General description
Research area: Cell signaling
Ferritin is a major iron storage protein. It exists in a two functionally and genetically different subunits namely, the acidic, heavy or H-chain and the basic, light or L-chain. Native ferritin from human liver. Sterile-filtered.
Ferritin is a major iron storage protein. It exists in a two functionally and genetically different subunits namely, the acidic, heavy or H-chain and the basic, light or L-chain. Native ferritin from human liver. Sterile-filtered.
Application
Ferritin is suitable for use in immunofluorescence assay, immunoassays, as an immunogen, and in enzyme/radiolabeling.
Biochem/physiol Actions
Ferritin is a crucial protein that has multiple functions in iron metabolism and immune regulation. It helps in maintaining the iron balance. H-ferritin is involved in various processes such as regulating immune function, hematopoiesis, hepatocyte apoptosis, and cell differentiation. Additionally, ferritin can act as a proinflammatory cytokine through protein kinase C-zeta (PKC-ζ) and nuclear factor kappa B (NFκB) signaling pathways in certain cells.(1) Ferritin serves as both an immune-suppressor and a signaling molecule, contributing to the regulation of lymphoid and myeloid cell proliferation.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 0.9% NaCl, 0.1% NaN₃, pH 7.0.
Other Notes
Addison, J.M., et al. 1983. FEBS Lett.164, 139.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ferritin, iron homeostasis, and oxidative damage
Arosio P and Levi S
Free radical biology & medicine, 33(4), 457-463 (2002)
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity
Recalcati S, et al.
Journal of Autoimmunity, 30(1-2), 84-89 (2008)
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
Ruddell RG, et al.
Journal of Separation Science, 49(3), 887-900 (2009)
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
Ruddell RG, et al.
Hepatology, 49(3), 887-900 (2009)
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity
Recalcati S, et al.
Journal of Autoimmunity, 30(1-2), 84-89 (2008)
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