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Key Documents

324890

Sigma-Aldrich

E-64 Protease Inhibitor

The E-64 Protease Inhibitor, also referenced under CAS 66701-25-5, controls the biological activity of E-64 Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

E-64 Protease Inhibitor, (2 R,3 R)-3-(( S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L- trans-​3-​Carboxyoxira, (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-R

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About This Item

Empirical Formula (Hill Notation):
C15H27N5O5
CAS Number:
66701-25-5
Molecular Weight:
357.41
MDL number:
MFCD00080261
UNSPSC Code:
12352200
NACRES:
NA.77
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description

RTECS - RR0390000

Quality Level

200

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 20 mg/mL
DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

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Nalgene® baffled shake flask flask capacity 500 mL, Straight neck

F0277

Nalgene® baffled shake flask

Nalgene® baffled shake flask flask capacity 250 mL, Beaded neck

F0152

Nalgene® baffled shake flask

Nalgene® baffled shake flask flask capacity 1,000 mL, Straight neck

F0402

Nalgene® baffled shake flask

Nalgene® baffled shake flask capacity 2,000 mL, Beaded neck

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Nalgene® baffled shake flask

manufacturer/tradename

Nalgene® 4110-0500

manufacturer/tradename

Nalgene® 4110-0250

manufacturer/tradename

Nalgene® 4110-1000

manufacturer/tradename

Nalgene® 4110-2000

material

straight neck transparent polycarbonate flask

material

beaded neck transparent polycarbonate flask

material

straight neck transparent polycarbonate flask

material

beaded neck translucent polycarbonate flask, transparent polycarbonate

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

feature

graduations 50 mL (Marked every 25mL at 400 - 500mL range), without cap

feature

cap: no, graduations 25 mL, without cap

feature

without cap

feature

graduations 200 mL, without cap

packaging

case of 4

packaging

case of 4

packaging

case of 2 ea

packaging

case of 2

General description

Irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.

Biochem/physiol Actions

Cell permeable: no
Primary Target
cysteine proteases
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Matsumoto, K., et al. 1999. Biopolymers51, 99.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J.201, 189.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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