324745
Elastase Inhibitor III
The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Elastase Inhibitor III, HLE Inhibitor, MeOSuc-AAPV-CMK
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About This Item
Empirical Formula (Hill Notation):
C22H35ClN4O7
Molecular Weight:
502.99
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white
solubility
DMSO: 10 mg/mL
methanol: soluble
shipped in
ambient
storage temp.
−20°C
General description
A potent inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
A potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki = 10 µM). Protects against lung injury induced by instillation of elastase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Human leukocyte elastase (HLE)
Human leukocyte elastase (HLE)
Product does not compete with ATP.
Reversible: no
Target Ki: 10 µM against human leukocyte elastase (HLE)
Warning
Toxicity: Standard Handling (A)
Sequence
MeOSuc-Ala-Ala-Pro-Val-CMK
Reconstitution
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis.141, 672.
Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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