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324628

EGTA/AM

Name: EGTA/AM
Brand: MM

Membrane-permeable form of the Ca2+-chelating agent EGTA.

Synonym(s):

EGTA/AM, Ethyleneglycol- bis(β-aminoethyl)-N,N,Nʹ,Nʹ-tetraacetoxymethyl Ester, Ethyleneglycol-bis(β-aminoethyl)-N,N,Nʹ,Nʹ-tetraacetoxymethyl Ester

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₄₀N₂O₁₈

CAS Number:

99590-86-0

Molecular Weight:

668.60

UNSPSC Code:

12352108

NACRES:

NA.25

Quality Level

100

Assay

≥95% (HPLC)

form

oil

reaction suitability

reagent type: chelator

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

light yellow

solubility

DMSO: 20 mg/mL
DMF: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C26H40N2O18/c1-19(29)39-15-43-23(33)11-27(12-24(34)44-16-40-20(2)30)5-7-37-9-10-38-8-6-28(13-25(35)45-17-41-21(3)31)14-26(36)46-18-42-22(4)32/h5-18H2,1-4H3

InChI key

GNJXVFXIDHCCKR-UHFFFAOYSA-N

Related Categories

Chelating & Reducing Agents for Research

General description

Membrane-permeable form of the Ca²⁺-chelating agent EGTA.

Membrane-permeable version of the Ca²⁺-chelating agent EGTA (Cat. No. 324625). Induces apoptosis in pheochromocytoma (PC12) cells.

Application

Arresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage.: Researchers explored the effects of calcium regulation on sperm metabolism, demonstrating that EGTA/AM can arrest calcium dynamics, significantly enhancing the storage and fertility of poultry semen. This finding could have broad implications for agricultural practices and poultry breeding programs (Sushadi et al., 2023).

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Garcia, J.G., et al. 1992. Blood79, 2056.
Kuriyama, S., et al. 1992. Brain Res.579, 227.
Maki, A., et al. 1992. FASEB J.6, 919.
Negre-Salvayre, A., and Salvayre, R. 1992. Biochim. Biophys. Acta 1123, 207.
Ichinose, M., et al. 1992. Biochem. Biophys. Res. Commun.182, 372.
Hong, M., and Moody, T.W. 1991. Peptides12, 1315.
Schnellmann, R.G. 1991. J. Biochem. Toxicol.6, 299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)