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Synonym(s):
EDTA, 500 mM Solution, pH 8.0, ULTROL® Grade
Empirical Formula (Hill Notation):
C10H16N2O8
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Quality Level
form
solution
reaction suitability
reagent type: chelator
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
concentration
500 mM
color
colorless to pale yellow
pH
8
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)
InChI key
KCXVZYZYPLLWCC-UHFFFAOYSA-N
Related Categories
General description
A useful agent for radioimmunoimaging.
Ethylenediaminetetraacetic acid (EDTA) is a metal chelating agent, which is used in treating patients with heavy-metal poisonings like lead or mercury. It is also used to minimize the non-specific serum protein interactions in enzyme immunoassays. Due to its ability to inhibit protein agglutination, it is useful to make blood/plasma samples and in immunoanalysis to detect CD3 cells. EDTA combines with buffers or ionic salts to stimulate the immune cells in the blood samples. It is used in multiple aspects to treat and analyze psoriasis. EDTA functions as an antioxidant to combat psoriasis, while it is also used to understand the disease at a molecular level.
Application
EDTA, 500 mM Solution, pH 8.0, ULTROL® Grade has been used along with phosphate buffer saline (PBS) for cell disruption to harvest crypts in situ hybridization of nematodes. It has also been used as a component of isoelectric focusing solution (IEF) to resuspend myofibrils for protein studies.
Warning
Toxicity: Irritant (B)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Amreen Sunil et al.
Cureus, 13(7), e16424-e16424 (2021-07-20)
Psoriasis is a long-term, autoimmune inflammatory condition characterized by red, scaly plaques that can range from a few patches to total skin coverage. Over the past 60 years, and more recently, the metal-chelating agent ethylenediaminetetraacetic acid (EDTA) has proven increasingly
M P Richards et al.
Journal of chromatography, 402, 243-256 (1987-07-31)
Reversed-phase high-performance liquid chromatography (RP-HPLC) was used to isolate, characterize and quantitate liver and kidney metallothionein (MT) isoforms from a variety of animal species. The isoMTs were eluted from a radially compressed C18 column with a neutral sodium phosphate buffer
Krishnan MohanKumar et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(4), G705-G716 (2020-02-25)
Anemia is a frequent diagnosis in critically ill infants, but the clinical implications of severe anemia in these patients remain unclear. In this study, we examined preweaned mice to investigate the effects of severe anemia during early infancy on gut
Walter E Knight et al.
STAR protocols, 2(4), 100912-100912 (2021-11-11)
When cultured under typical conditions, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are structurally and functionally immature. We have previously demonstrated that culture of hiPSC-CMs in maturation medium containing fatty acids, in combination with culture on micropatterned surfaces, produces cells that
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