317641
Dipeptidylpeptidase IV Inhibitor III
The Dipeptidylpeptidase IV Inhibitor III, also referenced under CAS 866396-34-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Synonym(s):
Dipeptidylpeptidase IV Inhibitor III, 1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
Empirical Formula (Hill Notation):
C14H20N4O2 · xHCl
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
PBS: 20 mg/mL
ethanol: 20 mg/mL
water: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Wright, S.W., et al. 2006. J. Med. Chem.49, 3068.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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