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317505

Sigma-Aldrich

1,2-Dioctanoyl-sn-glycerol

Cell-permeable activator of protein kinase C (PKC).

Synonym(s):

1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV

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About This Item

Empirical Formula (Hill Notation):
C19H36O5
CAS Number:
60514-48-9
Molecular Weight:
344.49
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

clear colorless

solubility

chloroform: soluble
ethyl acetate: soluble

shipped in

wet ice

storage temp.

−70°C

InChI

1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1

InChI key

ZQBULZYTDGUSSK-KRWDZBQOSA-N

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKCα than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.
Cell-permeable activator of protein kinase C; however, it has lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Protein kinase C
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Analysis Note

Single spot by TLC

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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