260913
DNase I, Bovine Pancreas
Native DNase I from bovine pancreas.
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Synonym(s):
DNase I, Bovine Pancreas, Deoxyribonuclease I
CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.54
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biological source
bovine pancreas
form
lyophilized
specific activity
≥60,000 dornase units/mg dry wt
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
solubility
sodium acetate buffer: soluble
water: soluble
shipped in
ambient
storage temp.
−20°C
General description
Native DNase I from bovine pancreas. An endonuclease that preferentially cleaves phosphodiester linkages adjacent to pyrimidine nucleotides to yield 5′-phosphate terminated polynucleotides with a free hydroxyl group at the 3′ position. Acts on single and double stranded DNA. Note: 1 MU = 1,000,000 Dornase units
Note: 32 Dornase units equal ~1 Kunitz unit; 1 MU = 1,000,000 Dornase units.
Warning
Toxicity: Standard Handling (A)
Unit Definition
One Dornase unit is defined as the amount of enzyme that will cause a decrease of 1.0 relative viscosity unit in a solution of highly polymerized DNA from the initial relative viscosity of 4.0 in 10 min at 30°C.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Takeshita, H., et al. 2000. Biochem. Biophys. Res. Commun.269, 481.
Jones, S.J., et al. 1996. J. Mol. Biol.264, 1154.
Jones, S.J., et al. 1996. J. Mol. Biol.264, 1154.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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