Skip to Content
Merck
CN

251530-M

Dafadine-A

Synonym(s):

Dafadine-A, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A, (5-((2,6-Dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone, 4-(1-((5-((2,6-Dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C23H25N3O3
Molecular Weight:
391.46
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

storage temp.

2-8°C

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light beige

solubility

DMSO: 100 mg/mL

General description

A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20 µM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C.elegans (at ~25 µM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Luciani, G.M., et al. 2011. Nat. Chem. Biol.7, 891.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

545.7 - 659.1 °F

flash_point_c

285.4 - 348.4 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service