240896
Cystatin C, Human Urine
A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane.
Synonym(s):
Post γ-globulin
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About This Item
UNSPSC Code:
12352200
Quality Level
Assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
0.1 M sodium acetate, pH 4.5: soluble
shipped in
ambient
storage temp.
2-8°C
General description
A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (Ki = 0.26 nM) and cathepsin B (Ki = 4.4 nM). Thought to be linked to many disease processes including Alzheimer′s Disease, hereditary cerebral hemorrhage and lung cancer.
A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cysteine protease
Cysteine protease
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 20 mM NH₄HCO₃.
Preparation Note
Prepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
Other Notes
Hall, A., et al. 1998. Biochemistry37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest.56, 409.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest.56, 409.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Sebastien A Gauthier et al.
Methods in molecular biology (Clifton, N.J.), 849, 275-287 (2012-04-25)
Neuronal cell culture models have been used to demonstrate the protective effects of cystatin C against a variety of insults, including the toxicity induced by oligomeric and fibrillar amyloid β (Aβ). Here, we describe assays quantifying cystatin C protective effects
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