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Merck
CN

239900

Cypermethrin

Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.

Synonym(s):

Cypermethrin

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About This Item

Empirical Formula (Hill Notation):
C22H19Cl2NO3
CAS Number:
52315-07-8
Molecular Weight:
416.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00055328

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Product Name

Cypermethrin, Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.

SMILES string

ClC(=CC1C(C1C(=O)OC(c2cc(ccc2)Oc3ccccc3)C#N)(C)C)Cl

InChI

1S/C22H19Cl2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3

InChI key

KAATUXNTWXVJKI-UHFFFAOYSA-N

description

Merck USA index - 14, 2767

assay

≥95% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: 15 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Richter, A., et al. 1995. Biochem. Pharmacol.49, 367.
Wang, J.H., and Stelzer, A. 1994. NeuroReport 5, 2377.
Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol.43, 1777.
Narahasi, T. 1992. Trends Pharmacol. Sci.13, 236.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Biochem/physiol Actions

Primary Target
calcineurin
Product does not compete with ATP.
Target IC50: 40 pM against calcineurin (protein phosphatase 2B

Disclaimer

Toxicity: Toxic (F)

General description

Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.
Type II pyrethroid insecticide. Potent inhibitor of calcineurin (protein phosphatase 2B, IC50 = 40 pM). May also have varied effects on ion channels.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3

target_organs

Nervous system, Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

Regulatory Information

新产品
This item has

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