C-Reactive Protein, Human, Recombinant, E. coli

M.W. 23,000 (monomer); 115,000 (pentamer).

Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera.Calibrated by electroimmunoassay against WHO reference standard or equivalent.

Toxicity: Standard Handling (A)

In 140 mM NaCl, 20 mM Tris-HCl, 2 mM CaCl₂, 0.05% NaN₃, pH 7.5.

Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol.24, 975.
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Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.

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