234109-M
Colcemid
Cell synchronization agent.
Synonym(s):
Colcemid, Demecolcine
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About This Item
Empirical Formula (Hill Notation):
C21H25NO5
CAS Number:
Molecular Weight:
371.43
MDL number:
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
form
crystalline powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
chloroform: 10 mg/mL
ethanol: soluble
storage temp.
10-30°C
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
InChI key
NNJPGOLRFBJNIW-UHFFFAOYSA-N
General description
Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Biochem/physiol Actions
Primary Target
Depolymerizes microtubules and limits microtubule formation.
Depolymerizes microtubules and limits microtubule formation.
Warning
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Regulatory Information
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