219419
Cathepsin Inhibitor III
The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Cathepsin Inhibitor III, Z-FG-NHO-BzOME
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About This Item
Empirical Formula (Hill Notation):
C27H27N3O7
Molecular Weight:
505.52
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
>90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
protect from light
color
white
solubility
ethanol: 1 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
General description
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Biochem/physiol Actions
Cell permeable: no
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Phe-Gly-NHO-Bz-pOMe
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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