Coagulation Factor V, Human Plasma

Native coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca²⁺, and membrane phospholipids are cofactors that form a "prothrombinase" complex with Factor X, enabling its proteolytic activation of prothrombin to thrombin.

Native coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca²⁺, and membrane phospholipids are cofactors which form a "prothrombinase" complex with Factor Xa, enabling its proteolytic activation of prothrombin to thrombin.

Please refer to vial label for lot-specific concentration.

Toxicity: Standard Handling (A)

In 50% glycerol/H₂O (v/v).

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Following initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

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Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem.265, 17132.
Krishnaswamy, S., et al. 1989. J. Biol. Chem.264, 3160.
Lee, C.D., and Mann, K.G. 1989. Blood73, 185.
Krieg, U.C., et al. 1987. Biochemistry26, 103.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.