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Merck
CN

219012

Caspase-3 Inhibitor VII

The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-3 Inhibitor VII, 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate

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About This Item

Empirical Formula (Hill Notation):
C20H21N3O7S
CAS Number:
745046-84-8
Molecular Weight:
447.46
UNSPSC Code:
12352200

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Product Name

Caspase-3 Inhibitor VII, The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

InChI key

MWXJJTMEUGWKKY-UHFFFAOYSA-N

InChI

1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3

assay

≥95% (HPLC)

form

solid

potency

23 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: yes
Primary Target
capase-3
Product does not compete with ATP.
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

Other Notes

Kravchenko, D.V., et al. 2005. J. Med. Chem.48, 3680.

Packaging

Packaged under inert gas

General description

A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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