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Merck
CN

218840

Caspase-8 Inhibitor II

InSolution

Synonym(s):

InSolution Caspase-8 Inhibitor II, Granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C30H43FN4O11
Molecular Weight:
654.68
NACRES:
NA.54
UNSPSC Code:
12352200

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Product Name

Caspase-8 Inhibitor II, InSolution

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Analysis Note

≥98% (HPLC)

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-8
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

Other Notes

Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Packaging

Packaged under inert gas

Physical form

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

Certificates of Analysis (COA)

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