218753
Caspase-5 Inhibitor I
Single spot by TLC, solid, Caspase-5 inhibitor, Calbiochem®
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Synonym(s):
Caspase-5 Inhibitor I, Z-WE(OMe)HD(OMe)-FMK
Empirical Formula (Hill Notation):
C37H42FN7O10
Molecular Weight:
763.77
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
A potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1, caspase-4, caspase-5, caspase-8
caspase-1, caspase-4, caspase-5, caspase-8
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Analysis Note
single spot by TLC
Other Notes
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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