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216201

Sigma-Aldrich

Carboxyatractyloside, Potassium Salt, Xanthium sibiricum - CAS 35988-42-2 - Calbiochem

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Synonym(s):
Carboxyatractyloside, Potassium Salt, Xanthium sibiricum - CAS 35988-42-2 - Calbiochem, C-ATR, CAT
Empirical Formula (Hill Notation):
C31H43K3O18S2 · 3H2O
CAS Number:
35988-42-2
Molecular Weight:
939.13
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C31H46O18S2.2K/c1-14(2)9-21(33)47-24-23(49-51(42,43)44)22(48-50(39,40)41)18(13-32)46-26(24)45-17-11-29(4)19-6-5-16-10-30(19,25(34)15(16)3)8-7-20(29)31(12-17,27(35)36)28(37)38;;/h14,16-20,22-26,32,34H,3,5-13H2,1-2,4H3,(H,35,36)(H,37,38)(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/t16-,17?,18?,19?,20?,22?,23?,24?,25-,26?,29-,30+;;/m1../s1

InChI key

FPJGZZYAZUKPAD-NBKMCPERSA-L

General description

This product has been discontinued.



We are offering Carboxyatractyloside potassium salt (Cat. No. C4992) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






Toxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki<10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC).

CAS No. refers to that of the free acid.
Toxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki<10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC). CAS No. refers to that of the free acid.

Warning

Toxicity: Toxic (F)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Pebay-Peyroula, E., et al. 2003. Nature426, 39.
Huber, T., et al. 1999. Biochemistry38, 762.
Fiore, C., et al. 1998. Biochimie80, 137.
Lohret, T.A., et al. 1996. J. Biol. Chem.271, 4846.

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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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