All Photos(1)
Synonym(s):
CaMKII Inhibitor XII, Ca 2+/Calmodulin-Dependent Protein Kinase II Inhibitor XII
Empirical Formula (Hill Notation):
C29H30ClN5O2S
Molecular Weight:
548.10
UNSPSC Code:
12352200
NACRES:
NA.28
Recommended Products
Assay
≥99% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC50 = 0.063 µM) with excellent selectivity over several kinases (IC50 = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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