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208922-M

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CaMKII Inhibitor, CK59

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

CaMKII Inhibitor, CK59, 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59

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About This Item

Empirical Formula (Hill Notation):
C21H37N7O3
CAS Number:
140651-18-9
Molecular Weight:
435.56
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

semisolid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

storage temp.

2-8°C

InChI

1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)

InChI key

AYZRKFOEZQBUEA-UHFFFAOYSA-N

General description

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 µM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 µM) and GLUT4 membrane translocation (IC50 = 100 µM) in 3T3-L1 adipocytes.
A cell-permeable Olomoucine analog that acts as a CaMKII inhibitor (IC50<10 M) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 M) and GLUT4 membrane translocation (IC50 = 100 M) in 3T3-L1 adipocytes.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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