208711
Ca2+/Calmodulin Kinase II Inhibitor 281-309
The Ca2+/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca2+/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Ca2+/Calmodulin Kinase II Inhibitor 281-309, CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
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About This Item
Empirical Formula (Hill Notation):
C146H254N46O39S3
Molecular Weight:
3374.06
UNSPSC Code:
12352200
Quality Level
Assay
≥97% (HPLC)
form
lyophilized solid
potency
80 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A synthetic peptide containing the calmodulin binding site (290-309) and the autophosphorylation site (Thr286) of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II by blocking Ca2+/calmodulin activation (IC50 = 80 nM) and enzyme-active site (IC50 = 2 µM).
A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site (IC50 = 2 µM).
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Warning
Toxicity: Standard Handling (A)
Sequence
H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Other Notes
Waxham, M.N., et al. 1993. Biochemistry32, 2923.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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