204863
Complement iC3b, Human
Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.
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UNSPSC Code:
12352202
NACRES:
NA.25
Recommended Products
Quality Level
Assay
≥90% (SDS-PAGE)
form
liquid
does not contain
preservative
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
impurities
IgG, IgA, IgM, C5, Factor H, or Factor I, trace
shipped in
wet ice
storage temp.
−70°C
General description
Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43,000 and M.W. 63,000 are disulfide bonded to the intact C3 b-chain (M.W. 75,000). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Other Notes
Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol.153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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