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Merck
CN

204863

Complement iC3b, Human

Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

Synonym(s):

Complement iC3b, Human Complement iC3b, Human iC3b

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352202

Key Documents

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Product Name

Complement iC3b, Human, Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

assay

≥90% (SDS-PAGE)

form

liquid

does not contain

preservative

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, C5, Factor H, or Factor I, trace

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.

Other Notes

Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol.153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.

Packaging

Please refer to vial label for lot-specific concentration.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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