203984
2,3-Butanedione 2-Monoxime
An inhibitor of skeletal and cardiac muscle contraction.
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Synonym(s):
2,3-Butanedione 2-Monoxime, BDM
Empirical Formula (Hill Notation):
C4H7NO2
Recommended Products
Quality Level
Assay
≥98% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white to off-white
solubility
methanol: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+
InChI key
FSEUPUDHEBLWJY-HWKANZROSA-N
General description
An inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
Product does not compete with ATP.
Reversible: yes
Target IC50: 18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun.229, 154.
Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol.74, 305.
Zhu, Y., and Ikeda, S.R. 1993. Neurosci.Lett. 155, 24.
Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol.74, 305.
Zhu, Y., and Ikeda, S.R. 1993. Neurosci.Lett. 155, 24.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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