203820
Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt
Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.
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Synonym(s):
Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt, 8-Bromo-cGMP, Br-cGMP, Na
Empirical Formula (Hill Notation):
C10H10BrN5O7P · Na
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Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white
solubility
water: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1
InChI key
YUFCOOWNNHGGOD-UMMCILCDSA-N
Related Categories
General description
Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
protein kinase G
protein kinase G
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
Other Notes
Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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