203297-M
Bisindolylmaleimide IV
A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).
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Synonym(s):
Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
Empirical Formula (Hill Notation):
C20H13N3O2
Recommended Products
Quality Level
Assay
≥98% (TLC)
form
powder
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
dark orange
solubility
methanol: 10 mg/mL
storage temp.
2-8°C
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI key
DQYBRTASHMYDJG-UHFFFAOYSA-N
General description
A cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).
Biochem/physiol Actions
Primary Target
PKC
PKC
Target IC50: 87 nM against protein kinase C
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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