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Merck
CN

196871

BAY 11-7082

InSolution, ≥95%, Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α

Synonym(s):

InSolution BAY 11-7082

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About This Item

Empirical Formula (Hill Notation):
C10H9NO2S
Molecular Weight:
207.25
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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Product Name

BAY 11-7082, InSolution, ≥95%, Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α

assay

≥95% (HPLC)

form

liquid

potency

10 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TNF-α-inducible phosphorylation of IκBα
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.

Other Notes

Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

Packaging

Packaged under inert gas

Physical form

Supplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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Miriam Paz-Barba et al.
Diabetologia, 67(1), 124-136 (2023-11-04)
Inflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprotein L (APOL) family of genes has been associated with innate immunity and apoptosis in non-pancreatic cell types, but also with metabolic syndrome and type 2
Mariana Sponchiado et al.
Physiological reports, 9(3), e14749-e14749 (2021-02-14)
Substance P (SP) is a tachykinin that regulates airway mucous secretion in both health and disease. Our study aimed to determine whether overexpression of SP without pre-existing inflammation was sufficient to induce changes in mucin secretion and transport in small
Charlotte Kötting et al.
Cancers, 13(6) (2021-04-04)
Curcumin is known to have immune-modulatory and antitumor effects by interacting with more than 30 different proteins. An important feature of curcumin is the inhibition of nuclear factor kappa of activated B-cells (NF-κB). Here, we evaluate the potential of curcumin
Or Kalchiem-Dekel et al.
American journal of respiratory cell and molecular biology, 63(2), 185-197 (2020-04-28)
The primary function of APOE (apolipoprotein E) is to mediate the transport of cholesterol- and lipid-containing lipoprotein particles into cells by receptor-mediated endocytosis. APOE also has pro- and antiinflammatory effects, which are both context and concentration dependent. For example, Apoe-/-

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