189480-M
Autocamtide-2 Related Inhibitory Peptide
The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Autocamtide-2 Related Inhibitory Peptide, AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
Empirical Formula (Hill Notation):
C64H116N22O19
Molecular Weight:
1497.74
UNSPSC Code:
12352202
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
storage temp.
−20°C
General description
Non-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM) and is 50 and 500 times more potent than Ala286-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.
Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets.
Biochem/physiol Actions
Target IC50: 40 nM against calmodulin-dependent protein kinase II
Warning
Toxicity: Standard Handling (A)
Sequence
H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Other Notes
Bhat, H.S., et al. 2000. Biochem. Pharmacol.60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service