Skip to Content
Merck
CN
All Photos(1)

Documents

182517

Sigma-Aldrich

Arp2/3 Complex Inhibitor I, Inactive Control, CK-689

The Arp2/3 Complex Inhibitor I, Inactive Control, CK-689, also referenced under CAS 170930-46-8, controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Arp2/3 Complex Inhibitor I, Inactive Control, CK-689, N-(2-(1H-Indol-3-yl)ethyl)-2-methoxy-acetamide, CK-1828689

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C13H16N2O2
CAS Number:
Molecular Weight:
232.28
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable indolyl-methoxyacetamide that exhibits no Arp2/3 inhibitory activity and serves as an inactive control for CK-666 (Cat. No. 182515) in both cell-based and cell-free experiments.
A cell-permeable indolyl-methoxyacetamide that exhibits no Arp2/3 inhibitory activity and serves as an inactive control for CK-666 (Cat. No. 182515) in both cell-based and cell-free experiments.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Nolen, B.J., et al. 2009. Nature460, 1031.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Anshuman Bhanja et al.
eLife, 12 (2023-12-12)
Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifies signaling, while B-cell contraction following spreading leads to signal attenuation.
Giulia Cazzagon et al.
iScience, 26(7), 107129-107129 (2023-07-12)
Although the formin-nucleated actomyosin cortex has been shown to drive the changes in cell shape that accompany animal cell division in both symmetric and asymmetric cell divisions, the mitotic role of cortical Arp2/3-nucleated actin networks remain unclear. Here using asymmetrically
Domokos I Lauko et al.
Molecular biology of the cell, 32(16), 1433-1445 (2021-06-17)
The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), a pathogen of lepidopteran insects, has a striking dependence on the host cell actin cytoskeleton. During the delayed-early stage of infection, AcMNPV was shown to induce the accumulation of actin at the cortex of infected cells. However, the dynamics and
An ancestral mycobacterial effector promotes dissemination of infection.
Saelens, et al.
Cell, 185, 4507-4525 (2023)
Ashwathi S Mohan et al.
Developmental cell, 49(3), 444-460 (2019-05-08)
Actin assembly supplies the structural framework for cell morphology and migration. Beyond structure, this actin framework can also be engaged to drive biochemical signaling programs. Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1P29S) in melanoma

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service