178479
Anti-Apolipoprotein E Goat pAb
liquid, Calbiochem®
Synonym(s):
Anti-ApoE antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
goat
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, rat, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Anti-Apolipoprotein E, goat polyclonal, recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins. It is validated for ELISA, immunoprecipitation, and free-floating sections.
Goat polyclonal antibody supplied as serum that has been defibrinated, delipidized and dialyzed against a Tris-HCl buffer. Recognizes the apolipoprotein E protein.
Recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins.Antibody Target Gene Symbol: APOE Target Synonym: AD2, AI255918, APOE2, APOE4, APOEA, APOLIPOPROTEIN E, LDLCQ5, LPG, MGC1571 Entrez Gene Name: apolipoprotein E Hu Entrez ID: 348 (Related Antibodies: NE1004) Mu Entrez ID: 11816 Rat Entrez ID: 25728
Immunogen
Human
purified recombinant human apolipoprotein E
Application
ELISA (1:8000)
Immunoprecipitation (see comments)
Free Floating Sections (see application references)
Immunoprecipitation (see comments)
Free Floating Sections (see application references)
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Monospecific as determined by immunoelectrophoresis (IEP) against twice concentrated pooled human serum. This antibody has also been reported to work with immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Emilie L Castranio et al.
Neurobiology of disease, 105, 1-14 (2017-05-16)
Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset
Jin-Dong Ding et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(28), E279-E287 (2011-06-22)
Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have been implicated previously in the AMD disease process. Consistent with a pathogenic role for Aβ, we show here
Nicholas F Fitz et al.
Journal of Alzheimer's disease : JAD, 41(2), 535-549 (2014-03-20)
Passive amyloid-β (Aβ) vaccination has shown significant effects on amyloid pathology in pre-depositing amyloid-β protein precursor (AβPP) mice but the results in older mice are inconsistent. A therapeutic effect of LXR and RXR agonists consisting of improved memory deficits and
Suzanne E Wahrle et al.
The Journal of clinical investigation, 118(2), 671-682 (2008-01-19)
APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(-/-) mice have decreased lipid associated with apoE and increased amyloid
Elizabeth S Chan et al.
Scientific reports, 6, 26119-26119 (2016-05-18)
The apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for Alzheimer's disease (AD). The AD brain was shown to be insulin resistant at end stage, but the interplay between insulin signaling, ApoE4 and Aβ across time, and their involvement
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