178456
Apolipoprotein B, Human Plasma, Low-Density Lipoprotein
Native apolipoprotein B from human plasma. It is a dominant protein constituent of LDL and VLDL. Acts as a ligand for LDL receptor, directing clearance of LDL from plasma to the liver.
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Synonym(s):
Apo B, Apo B-100
UNSPSC Code:
12352202
NACRES:
NA.25
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Quality Level
Assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
shipped in
ambient
storage temp.
−20°C
General description
Native apolipoprotein B from human plasma. Native apoplipoprotein B from human plasma. Dominant protein constituent of LDL and also present in VLDL. Ligand for the LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Produced by the liver. Mean serum concentration: 950 µg/ml.
Native apolipoprotein B from human plasma. Produced by the liver, and is a dominant protein constituent of LDL that is also present in VLDL. Ligand for LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Mean serum concentration: 950 µg/ml. Higher levels are reported in familial hyperlipidemia, obesity, and diabetes.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 50 mM Na₂CO₃, 50 mM NaCl, 10 mM sodium deoxycholate, pH 10.0.
Preparation Note
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Please refer to the label for lot-specific reconstitution volume.
Other Notes
Jiang, X.C., et al. 2001. Nat. Med.1, 847.
Zhou, M., et al. 1995. J. Biol. Chem.270, 25220.
Sivaram, P., et al. 1993. J. Biol. Chem.269, 9409.
Sato, R., et al. 1990. J. Biol. Chem. 265, 11880.
Zhou, M., et al. 1995. J. Biol. Chem.270, 25220.
Sivaram, P., et al. 1993. J. Biol. Chem.269, 9409.
Sato, R., et al. 1990. J. Biol. Chem. 265, 11880.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Andrzej S Pitek et al.
PloS one, 7(7), e40685-e40685 (2012-07-26)
It is now well established that the surface of nanoparticles (NPs) in a biological environment is immediately modified by the adsorption of biomolecules with the formation of a protein corona and it is also accepted that the protein corona, rather
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