176901
Anthrax Lethal Factor Protease Inhibitor, In-2-LF
The Anthrax Lethal Factor Protease Inhibitor, In-2-LF controls the biological activity of Anthrax Lethal Factor Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Synonym(s):
Anthrax Lethal Factor Protease Inhibitor, In-2-LF, Anthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
Empirical Formula (Hill Notation):
C81H150N42O17
Molecular Weight:
1984.33
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
5% acetic acid: 5 mg/mL
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
anthrax LF metalloprotease
anthrax LF metalloprotease
Product does not compete with ATP.
Reversible: no
Target Ki: 1 nM against Anthrax lethal factor (LF) metalloprotease
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun.321, 601.
Tonello, F., et. al. 2002. Nature418, 386.
Tonello, F., et. al. 2002. Nature418, 386.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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