176880
Anisomycin, Streptomyces griseolus
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.
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Synonym(s):
Anisomycin, Streptomyces griseolus, 2-( p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
Empirical Formula (Hill Notation):
C14H19NO4
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Quality Level
Assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 100 mg/mL
methanol: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
InChI key
YKJYKKNCCRKFSL-BFHYXJOUSA-N
General description
Activates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Warning
Toxicity: Toxic (F)
Reconstitution
Following reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
监管及禁止进口产品
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Madeleine Scharf et al.
Molecular and cellular biology, 33(13), 2586-2602 (2013-04-24)
The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3) represent protein kinases downstream of the p38 MAPK. Using MK2/3 double-knockout (MK2/3(-/-)) mice, we analyzed the role of MK2/3 in cross-striated muscle by transcriptome and proteome analyses and by
Chunchu Deng et al.
Journal of cell science, 134(22) (2021-10-21)
In neurons, the endoplasmic reticulum (ER) forms a highly dynamic network that enters axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse maintenance; however, the underlying mechanisms involved in regulation of its dynamic remodeling as
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