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Merck
CN

176870

Angiotensinogen, Human Plasma

Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.

Synonym(s):

Angiotensinogen, Human Plasma, AGT, AGT Angiotensinogen, Human Plasma Serpin A8 Hypertensinogen, Renin Substrate, Hypertensinogen, Serpin A8

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About This Item

CAS Number:
11002-13-4
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00151759

Key Documents

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Product Name

Angiotensinogen, Human Plasma, Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.

assay

≥95% (SDS-PAGE)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

technique(s)

cell based assay: suitable

solubility

water: soluble

NCBI accession no.

NM_001384479

UniProt accession no.

P01019

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

human ... AGT(183)

Application

Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.

Biochem/physiol Actions

Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)

General description

Research area: CELL SIGNALING

Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.

Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.

Other Notes

Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.

Physical form

Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Please refer to vial label for lot-specific concentration prior to lyophilization.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hepatic disorders
Anika Niambi Al-Shura
Journal of Separation Science, 6, 115-122 (2021)
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
Hassani B, et al.
Cancer Cell International, 23(1), 254-254 (2023)
Quantification and Characterization of Pregnancy-associated Complexes of Angiotensinogen and the Proform of Eosinophil Major Basic Protein in Serum and Amniotic Fluid
Christiansen M, et al.
Clinical Chemistry, 46(8), 1099?1105-1099?1105 (2000)
Physiology, renin angiotensin system
Fountain JH, et al.
StatPearls [Internet] (2023)
Structure and functions of angiotensinogen
Lu H, et al.
Hypertension Research, 39(7), 492-500 (2016)

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