176870
Angiotensinogen, Human Plasma
Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.
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Synonym(s):
Angiotensinogen, Human Plasma, AGT, Hypertensinogen, Serpin A8
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Quality Level
Assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
technique(s)
cell based assay: suitable
solubility
water: soluble
NCBI accession no.
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... AGT(183)
General description
Research area: CELL SIGNALING
Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.
Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.
Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.
Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.
Application
Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.
Biochem/physiol Actions
Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.
Preparation Note
Please refer to vial label for lot-specific concentration prior to lyophilization.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Hepatic disorders
Anika Niambi Al-Shura
Journal of Separation Science, 6, 115-122 (2021)
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
Hassani B, et al.
Cancer Cell International, 23(1), 254-254 (2023)
Physiology, renin angiotensin system
Fountain JH, et al.
StatPearls [Internet] (2023)
Quantification and Characterization of Pregnancy-associated Complexes of Angiotensinogen and the Proform of Eosinophil Major Basic Protein in Serum and Amniotic Fluid
Christiansen M, et al.
Clinical Chemistry, 46(8), 1099?1105-1099?1105 (2000)
Structure and functions of angiotensinogen
Lu H, et al.
Hypertension Research, 39(7), 492-500 (2016)
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