176708
Angiostatin K1-3, Human, Recombinant, E. coli
Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.
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Synonym(s):
Ang K1-3, K1-3, rHuAng K1-3
UNSPSC Code:
12352203
NACRES:
NA.77
Recommended Products
recombinant
expressed in E. coli
Quality Level
Assay
≥95% (HPLC and SDS-PAGE)
form
lyophilized powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
solubility
aqueous buffer containing 0.1% BSA: soluble
water: soluble
shipped in
wet ice
storage temp.
−20°C
General description
Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Certificates of Analysis (COA)
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