171601
Amyloid Precursor Protein β-Secretase Inhibitor
The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
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Synonym(s):
Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
Empirical Formula (Hill Notation):
C73H118N16O27
Molecular Weight:
1651.81
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
aqueous buffer, pH 7.5: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC50 = 30 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
APP
APP
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM against amyloid precursor protein (APP) β-secretase
Warning
Toxicity: Standard Handling (A)
Sequence
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sinha, S., et al. 1999. Nature 402, 537.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Zhi-Hao Wang et al.
Progress in neurobiology, 202, 102032-102032 (2021-03-16)
ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription factor, is upregulated in AD
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