16-246
Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor™ 488
clone LA1, Upstate®, from mouse
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UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
LA1, monoclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunofluorescence: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... EGFR(1956)
mouse ... Egfr(13649)
rat ... Egf(25313)
General description
Included Negative Control: Catalog # 16-240, Alexa Fluor™ 488-conjugated Normal Mouse IgG.
Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.
Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.
Specificity
external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors.
Immunogen
Human A431 membrane proteins
Application
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.
Quality
Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells.
Storage and Stability
1 year at 4°C from date of shipment
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Certificates of Analysis (COA)
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Matthew J Crow et al.
AJR. American journal of roentgenology, 192(4), 1021-1028 (2009-03-24)
The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. EGFR expression was quantified using both imaging methods in four cell lines: A431 human
Cetuximab.
Goldberg, Richard M
Nature Reviews. Drug Discovery, Suppl, S10-S11 (2005)
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.
Bianco, Roberto, et al.
Endocrine-Related Cancer, 12 Suppl 1, S159-S171 (2005)
Epidermal growth factor inhibition in solid tumours.
Ganti, Apar Kishor and Potti, Anil
Expert opinion on biological therapy, 5, 1165-1174 (2005)
Matthew J Crow et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(1), 57-65 (2010-12-25)
Fluorescence-based flow cytometry measures multiple cellular characteristics, including levels of receptor expression, by assessing the fluorescence intensity from a population of cells whose cell surface receptors are bound by a fluorescently labeled antibody or ligand for that receptor. Functionalized noble
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