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Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor™ 555

clone 4F11, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702

biological source

mouse

conjugate

ALEXA FLUOR™ 555

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4F11, monoclonal

species reactivity

bovine, human, rat, mouse, avian, hamster

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_005231.2
NM_138565.1

UniProt accession no.

Q14247

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CTTN(2017)

Specificity

Recognizes Cortactin in rodent and human cells

Immunogen

Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src

Application

Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor 555 detects level of Cortactin (p80/85) & has been published & validated for use in FC, IF, WB & IC.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

Quality

Routinely evaluated by immunoblot.

Target description

Mr 80kDa and in avian cells, Mr 80kDa and 85kDa

Physical form

Protein G Purified

Storage and Stability

1 year at 4°C from date of shipment

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kelly M Bailey et al.
Neoplasia (New York, N.Y.), 18(8), 480-488 (2016-08-28)
Metastatic Ewing sarcoma has a very poor prognosis and therefore new investigations into the biologic drivers of metastatic progression are key to finding new therapeutic approaches. The tumor microenvironment is highly dynamic, leading to exposure of different regions of a
Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens.
Selbach, Matthias and Backert, Steffen
Trends in Microbiology, 13, 181-189 (2005)
Khemraj Singh Baghel et al.
Oncoimmunology, 5(7), e1196299-e1196299 (2016-09-14)
The potential of a tumor cell to metastasize profoundly depends on its microenvironment, or "niche" interactions with local components. Tumor-associated-macrophages (TAMs) are the most abundant subpopulation of tumor stroma and represent a key component of tumor microenvironment. The dynamic interaction
Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin.
Gunst, Susan J
The Biochemical Journal, 380, e7-e8 (2004)
Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control.
Lua, Bee Leng and Low, Boon Chuan
Febs Letters, 579, 577-585 (2005)
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