16-228
Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor™ 488
clone 4F11, Upstate®, from mouse
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UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4F11, monoclonal
species reactivity
bovine, human, mouse, rat, hamster, avian
manufacturer/tradename
Upstate®
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... CTTN(2017)
Related Categories
Specificity
Recognizes Cortactin in rodent and human cells
Immunogen
Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src
Application
Detect Cortactin (p80/85) using this Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor 488 validated for use in FC, IF, WB & IC.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Quality
Routinely evaluated by immunoblot.
Target description
Mr 80kDa and in avian cells, Mr 80kDa and 85kDa
Physical form
Protein G Purified
Storage and Stability
1 year at 4°C from date of shipment
Analysis Note
Control
Negative Control: Catalog # 16-240, Normal Mouse IgG, Alexa Fluor™ 488-conjugate.
Negative Control: Catalog # 16-240, Normal Mouse IgG, Alexa Fluor™ 488-conjugate.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor is a registered trademark of Molecular Probes, Inc.
Alexa Fluor is a registered trademark of Molecular Probes, Inc.
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin.
Gunst, Susan J
The Biochemical Journal, 380, e7-e8 (2004)
T Katsube et al.
The Journal of biological chemistry, 273(45), 29672-29677 (1998-10-29)
Cortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli. Human cortactin has been identified as a protein product of a putative oncogene
Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration.
Gomathinayagam, R; Muralidharan, J; Ha, JH; Varadarajalu, L; Dhanasekaran, DN
Genes & Cancer null
C Dehio et al.
The EMBO journal, 14(11), 2471-2482 (1995-06-01)
Shigella flexneri causes bacillary dysentery in humans by invading epithelial cells of the colon. Cell invasion occurs via bacterium-directed phagocytosis, a process requiring polymerization of actin at the site of bacterial entry. We show that invasion of HeLa cells by
C Guinebault et al.
The Journal of cell biology, 129(3), 831-842 (1995-05-01)
Thrombin-induced accumulation of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) but not of PtdIns(3,4,5,)P3 is strongly correlated with the relocation to the cytoskeleton of 29% of the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PtdIns 3-kinase) and is accompanied by a significant increase in
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